![]() ![]() ![]() As monolithic columns have a high binding capacity, flow rate and resolution, a CIM ® DEAE-8f tube monolithic column was selected for purification in this study. They are designed as porous channels rather than beads with different chemistries for different requirements. MethodsĬIM ® Monolith columns are single-piece columns made up of poly(glycidyl methacrylate co-ethylene dimethacrylate) as support matrix. Hence, the large-scale production of purified EV-71 is required for vaccine development, diagnosis and clinical trials. Inactivated EV-71 induces a strong, virus-neutralizing antibody response in animal models, protecting them against a lethal EV-71 challenge and it has been shown to elicit cross-neutralizing antibodies in human trials. The most effective way to control the disease caused by EV-71 is by vaccination thus a novel vaccine is urgently needed. It is a major concern for public health issues across Asia-Pacific region. Enterovirus 71 (EV-71) is a neurotropic virus causing Hand, Foot and Mouth Disease (HFMD) in infants and children under the age of five.
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May 2023
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